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KMID : 0379520220380020249
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한국독성학회지
2022 Volume.38 No. 2 p.249 ~ p.256
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Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma
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Kim Chae-Yeong
Kong Gye-Yeong
Lee Hyun-Ji
Tran Quangdon
Vo Thuy-Trang T.
Kwon So-Hee
Park Ji-Soo
Kim Seon-Hwan
Park Jong-Sun
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Abstract
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Scavenger receptor class F member 2 (SCARF2) is expressed by endothelial cells with very large cytoplasmic domains and is the second isotype, also known as scavenger receptor expressed by endothelial cells 2 (SREC-2). SREC-1 plays an important role in the binding and endocytosis of various endogenous and exogenous ligands. Many studies have been carried out on modified low-density lipoprotein internalization activity, but there have been few studies on SCARF2. Higher expression of SCARF2 has been found in glioblastoma (GBM) than normal brain tissue. Through analysis of The Cancer Genome Atlas database, it was confirmed that SCARF2 is widely expressed in GBM, and increased SCARF2 expression correlated with a poor prognosis in patients with glioma. The results of this study showed that the expression of SCARF2 is increased in GBM cell lines and patients, suggesting that SCARF2 may be a potential diagnostic marker and therapeutic molecule for cancers including glioma.
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KEYWORD
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SCARF2, Glioblastoma, Cancer, Biomarker, Endocytosis
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